Shao-Rui Chen Selected Research

Memantine (Namenda)

1/2022	Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow.
1/2021	α2δ-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy.
1/2016	Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain.
1/2014	Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords.
8/2009	Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.

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Shao-Rui Chen Research Topics

Disease

43	Neuralgia (Stump Neuralgia) 01/2023 - 02/2002
34	Pain (Aches) 01/2023 - 09/2002
24	Hyperalgesia 01/2023 - 02/2002
23	Hypersensitivity (Allergy) 01/2023 - 01/2014
11	Hypertension (High Blood Pressure) 04/2024 - 09/2014
11	Chronic Pain 01/2023 - 02/2002
8	Diabetic Neuropathies (Diabetic Neuropathy) 11/2019 - 11/2003
6	Neoplasms (Cancer) 01/2023 - 04/2013
5	Peripheral Nervous System Diseases (PNS Diseases) 05/2019 - 01/2016
5	Cardiomegaly (Heart Hypertrophy) 09/2017 - 03/2012
4	Ischemia 03/2022 - 02/2002
3	Brain Ischemia (Cerebral Ischemia) 01/2023 - 10/2018
3	Inflammation (Inflammations) 10/2022 - 01/2010
3	Brain Injuries (Brain Injury) 03/2022 - 10/2018
3	Peripheral Nerve Injuries 05/2019 - 09/2012
3	Painful Neuropathy 12/2017 - 08/2014
2	Epilepsy (Aura) 01/2023 - 09/2014
2	Postherpetic Neuralgia 01/2021 - 04/2005
2	Nervous System Diseases (Neurological Disorders) 01/2021 - 01/2021
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2020 - 10/2018
2	Hypertrophy 05/2017 - 01/2013
2	Fibrosis (Cirrhosis) 05/2017 - 01/2014
2	Multiple Sclerosis 12/2014 - 12/2009
2	Myasthenia Gravis 12/2014 - 12/2009
2	Spinal Cord Injuries (Spinal Cord Injury) 12/2014 - 12/2009
2	Myocardial Ischemia (Ischemic Heart Diseases) 09/2004 - 02/2002
1	Stroke (Strokes) 01/2023
1	Opioid-Related Disorders (Opiate Addiction) 01/2023
1	Wounds and Injuries (Trauma) 01/2023
1	Substance-Related Disorders (Drug Abuse) 01/2023
1	Ischemic Stroke 01/2023
1	Postoperative Pain 12/2022
1	Autoimmune Diseases (Autoimmune Disease) 12/2022

Drug/Important Bio-Agent (IBA)

31	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2023 - 08/2009
22	Analgesics (Analgesic Drugs)IBA 01/2023 - 02/2002
13	Opioid Analgesics (Opioids)IBA 01/2023 - 12/2002
12	Glutamic Acid (Glutamate)FDA Link 01/2023 - 02/2002
11	Gabapentin (Neurontin)FDA LinkGeneric 01/2023 - 04/2005
10	Morphine (MS Contin)FDA LinkGeneric 01/2023 - 06/2002
9	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2011
8	Calcineurin InhibitorsIBA 04/2024 - 04/2013
7	Tacrolimus (Prograf)FDA LinkGeneric 04/2024 - 04/2013
7	Peptides (Polypeptides)IBA 01/2022 - 10/2018
6	Angiotensin IIIBA 12/2023 - 03/2012
6	Paclitaxel (Taxol)FDA LinkGeneric 01/2023 - 11/2014
5	CalcineurinIBA 12/2022 - 04/2013
5	Opioid Receptors (Opioid Receptor)IBA 10/2022 - 04/2016
5	Memantine (Namenda)FDA Link 01/2022 - 08/2009
5	N-Methylaspartate (NMDA)IBA 01/2022 - 08/2009
5	Streptozocin (Streptozotocin)FDA Link 11/2019 - 06/2002
5	Small Interfering RNA (siRNA)IBA 12/2018 - 02/2012
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/2024 - 05/2014
4	CannabinoidsIBA 01/2022 - 06/2012
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2020 - 01/2005
4	Protein Kinase CIBA 01/2019 - 01/2016
4	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2011 - 09/2002
3	Pregabalin (Lyrica)FDA Link 01/2023 - 01/2019
3	Calcium Channels (Calcium Channel)IBA 01/2023 - 05/2019
3	AMPA Receptors (AMPA Receptor)IBA 01/2022 - 11/2019
3	resiniferatoxinIBA 01/2021 - 04/2003
3	CalpainIBA 10/2018 - 09/2012
3	Casein Kinase II (Casein Kinase 2)IBA 09/2014 - 05/2014
3	Cholinergic Agents (Cholinergics)IBA 11/2011 - 03/2003
2	Immunosuppressive Agents (Immunosuppressants)IBA 04/2024 - 12/2022
2	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 01/2018
2	AnionsIBA 03/2022 - 10/2020
2	CalciumIBA 01/2022 - 11/2019
2	iodoresiniferatoxinIBA 01/2019 - 09/2004
2	MuscarineIBA 12/2018 - 03/2003
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2017 - 09/2011
2	Atrial Natriuretic Factor (ANF)IBA 09/2017 - 05/2017
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2016 - 09/2012
2	ChloridesIBA 01/2016 - 09/2012
2	4-Aminopyridine (4 Aminopyridine)FDA Link 12/2014 - 12/2009
2	Glycine Receptors (Glycine Receptor)IBA 02/2014 - 06/2012
2	Biomarkers (Surrogate Marker)IBA 01/2014 - 01/2013
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2012 - 09/2010
2	Capsaicin (Zostrix)FDA Link 04/2005 - 04/2003
2	AcidsIBA 01/2005 - 02/2002
2	BradykininIBA 09/2004 - 02/2002
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 11/2003 - 09/2002
2	Neostigmine (Neostigmine Bromide)IBA 11/2003 - 03/2003
2	D-Penicillamine (2,5)- EnkephalinIBA 01/2003 - 12/2002
1	Carrier Proteins (Binding Protein)IBA 01/2023
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2023
1	Antidepressive Agents (Antidepressants)IBA 01/2023
1	Yohimbine (Yocon)IBA 01/2023
1	Amitriptyline (Elavil)FDA LinkGeneric 01/2023
1	(2- (2',6'- dimethoxy)phenoxyethylamino)methylbenzo- 1,4- dioxaneIBA 01/2023
1	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA 12/2022
1	Histones (Histone)IBA 11/2022
1	naltrindoleIBA 10/2022
1	salicylhydroxamic acid (SHAM)IBA 01/2022
1	1,1-dimethylbutyl-1-deoxy-Delta(9)-THCIBA 01/2022

Therapy/Procedure

19	Spinal Injections 01/2023 - 11/2003
7	Drug Therapy (Chemotherapy) 01/2023 - 11/2014
5	Ligation 01/2023 - 02/2002
3	Analgesia 12/2022 - 01/2019
1	General Anesthesia 12/2022
1	Organ Transplantation 12/2022